Abstract
<p>Hemangiosarcomas are tumors of mesenchymal origin, potentially deleterious, associated with areas of high vascularization. Tumor progression and growth are associated with these tumors’ ability to retain blood and give rise to tortuous blood vessels. They have a vast metastatic capacity, often occurring in organs such as the spleen, liver, and aorta artery. However, other sites may be affected, although less frequently, such as the third eyelid and the conjunctiva and cutaneous regions. This article aims to report the case of an 8-year-old female dog with a history of conjunctival hemangiosarcoma, in the medial region of the left eye, with a hemorrhagic appearance. The animal was submitted to the surgical procedure of enucleation after the involvement of the surgical margins in a previous histopathological examination.</p>References
Camboim AS, Benvenutti MEM, Oliveira EL, Vaz AFM, Silva NMR, Dantas AFM, et al. Manifestation of paraneoplastic syndrome in a dog with cutaneous hemangiosarcoma: case report. Braz J Vet Med. 2017;39(2):126-32. https://doi.org/10.29374/2527-2179.bjvm025016
Richardson S, Deykin AR. Surgical treatment of conjunctival hemangioma and hemangiosarcoma: a retrospective study of 52 dogs. Vet Ophthalmol. 2021;24(5):432-41. https://doi.org/10.1111/vop.12921
Kim J-H, Graef AJ, Dickerson EB, Modiano JF. Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives. Vet Sci. 2015;2(4):388-405. https://doi.org/10.3390/vetsci2040388
Guberman UC, Merlini NB, Perches CS, Fonzar JF, Sereno MG, Mamprim MJ, Ranzani JJT, Brandão CVS. Corneal hemangiosarcoma in a dog. Arq Bras Med Vet Zootec. 2015;67(2):343-6. https://doi.org/10.1590/1678-7685
Soares NP, Medeiros AA, Szabo MPJ, Guimaraes EC, Fernandes LG, Santos TR. Hemangiomas and Hemangiosarcomas in dogs: a retrospective study of 192 cases (2002-2014). Cienc Anim Bras. 2017;18:1-10. https://doi.org/10.1590/1089-6891v18e-30889
Pigatto JAT, Albuquerque L, Voll J, Driemeier D. Hemangiosarcoma of the third eyelid in a dog. Acta Sci Vet. 2015;43:91. Available from: https://www.ufrgs.br/actavet/43-suple-1/CR_91.pdf
Freitas J, Yi LC, Forlani GS. Canine hemangiosarcoma: review. Pubvet. 2019;13(8):1-9. https://doi.org/10.31533/pubvet.v13n8a389.1-9
Griffin MA, Culp WTN, Rebhun RB. Canine and feline hemangiosarcoma. Vet Record. 2021;189(9):e585. https://doi.org/10.1002/vetr.585
Hendrick MJ. Mesenchymal Tumors of the Skin and Soft Tissues. In: Tumors in Domestic Animals. 5th ed. Nova Jersey: Wiley-Blackwell; 2017. p. 142-75. https://doi.org/10.1002/9781119181200.ch5
Mulin C, Clifford CA. Histiocytic Sarcoma and Hemangiosarcoma Update. Vet Clin North Am Small Anim Pract. 2019,49(5):855-79. https://doi.org/10.1016/j.cvsm.2019.04.009
Multari D, Vascellari M, Mutinelli F. Hemangiosarcoma of the third eyelid in a cat. Vet Ophthalmol. 2002; 5(4):273-6. https://doi.org/10.1046/j.1463-5224.2002.00254.x
Pirie CG, Dubielzig RR. Feline conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of eight cases (1993–2004). Vet Ophthalmol. 2006;9(4):227-31. https://doi.org/10.1111/j.1463-5224.2006.00472.x
Hartley C, Ladlow J, Smith KC. Cutaneous haemangiosarcoma of the lower eyelid in an elderly white cat. J Feline Med Surg. 2007; 9(1):78-81. https://doi.org/10.1016/j.jfms.2006.05.011
Boo G, Caruso KA, Whittaker CJ, Smith JS, Lurie D, Nguyen S. Recurrent corneal hemangiosarcoma in a cat with subsequent extension into the orbit. Vet Ophthalmol. 2021;24(4):408-13. https://doi.org/10.1111/vop.12868
Pirie CG, Knollinger AM, Thomas CB, Dubielzig RR. Canine conjunctival hemangioma and hemangiosarcoma: a retrospective evaluation of 108 cases (1989-2004). Vet Ophthalmol. 2006;9(4):215-26. https://doi.org/10.1111/j.1463-5224.2006.00471.x
Paiva FN, Oliveira LC, Ferrari BS, Torquato LFB, Araújo DCC, Costa TS, Fernandes JI. Multimodal therapy in the treatment of canine cutaneous hemangiosarcoma. Cienc Anim. 2020;30(3):155-62.
Story AL, Wavreille V, Abrams B, Egan A, Cray M, Selmic LE. Outcomes of 43 small breed dogs treated for splenic hemangiosarcoma. Vet Surgery. 2020;49(6):1154-63. https://doi.org/10.1111/vsu.13470
Flores MM, Panziera W, Kommers GD, Irigoyen LF, Barros CSL, Fighera RA. Aspectos epidemiológicos e anatomopatológicos do hemangiossarcoma em cães: 40 casos (1965-2012). Pesquisa Veterinária Brasileira, 2012.32(12):1319-28. https://doi.org/10.1590/S0100-736X2012001200017
Smith AN. Hemangiosarcoma in dogs and cats. Vet Clin North Am Small Anim Pract. 2003;33(3):533-52. https://doi.org/10.1016/S0195-5616(03)00002-0
Culp WT, Weisse C, Kellogg ME, Gordon IK, Clarke DL, May LR, Drobatz KJ. Spontaneous hemoperitoneum in cats: 65 cases (1994–2006). J Am Vet Med Assoc. 2010;236(9):978-82. https://doi.org/10.2460/javma.236.9.978
Hammond TN, Pesillo-Crosby SA. Prevalence of hemangiosarcoma in anemic dogs with a splenic mass and hemoperitoneum requiring a transfusion: 71 cases (2003–2005). J Am Vet Med Assoc. 2008;232(4):553-8. https://doi.org/10.2460/javma.232.4.553
Boston SE, Higginson G, Monteith G. Concurrent splenic and right atrial mass at presentation in dogs with HSA: a retrospective study. J Am Anim Hosp Assoc. 2011;47(5):336-41. https://doi.org/10.5326/JAAHA-MS-5603
Andrade E, Dalegrave S, Andrade J, Flecke LR. Unilateral renal hemangiosarcoma in a dog: Case report. Pubvet. 2021; 15:1-7. https://doi.org/10.31533/pubvet.v15n05a817.1-7
Pascoli AL, Mendonça APR, Lira RN, De Nardi AB, Filho NPR. Primary conjunctival-sclero-corneal hemangiosarcoma in a feline: Case report. Medvep. 2014; 12(40): 214-6. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/vti-10689?lang=en
Souza RG, Kassab S, Barroso RMV, Oliveira RS, Simplício VA. Advancement flap for correction of hemangiosarcoma in the penile region of a dog: case report. Arq Cienc Vet Zool UNIPAR. 2020; 23(2):e2308. https://doi.org/10.25110/arqvet.v23i2cont.2020.7962
Faroni E, Sabattini S, Guerra D, Iannuzzi C, Chalfon C, Agnoli C, Stefanello D, Polton G, Ramos S, Aralla M, Ciaccini R, Foglia A, Okonji S, Marconato L. Timely adjuvant chemotherapy improves outcome in dogs with non-metastatic splenic hemangiosarcoma undergoing splenectomy. Vet Comp Oncol. 2023;1-8. https://doi.org/10.1111/vco.12875
Yamamoto S, Hoshi K, Hirakawa A, Chimura S, Kobayashi M, Machida N. Epidemiological, clinical and pathological features of primary cardiac hemangiosarcoma in dogs: a review of 51 cases. J Vet Med Sci. 2013;75(11):1433-41. https://doi.org/10.1292/jvms.13-0064
Scherrer NM, Lassaline M, Engiles J. Ocular and periocular hemangiosarcoma in six horses. Vet Ophthalmol. 2018;21(4):432-7. https://doi.org/10.1111/vop.12529
Cazalot G, Regnier A, Deviers A, Serra F, Lucas MN, Etienne CL, Letron IR. Corneal hemangiosarcoma in a cat. Vet Ophthalmol. 2011;14:117-21. https://doi.org/10.1111/j.1463-5224.2011.00928.x
Storms G, Naranjo C, Grauwels M. Concurrent squamous cell carcinoma and hemangiosarcoma in the cornea of a cat. Vlaams Diergen Tijds. 2016;85(1):31-5. https://doi.org/10.21825/vdt.v85i1.16405
Keywords
malignant aspect
mesenchymal tumors
ocular conjunctiva
oncology