Abstract
<p>The objective of the current study is to determine the effects of intravenous application of ozone on blood biometrics and blood chemistry in clinically health and horses. The research was descriptive and experimental, of a transversal type. Also, the type of sampling was non-probabilistic of convenience, where fourteen animals were selected, and distributed in three groups: A and B, made up of six animals each, and group C, made of two animals. Ozone was applied using the major autohemotherapy. The blood was obtained from the jugular vein (400 ml), using the SANO3® Kit Copyright 2017, Paolo Gobbi Frattini, Srl Italy (all rights reserved). The animals were sampled 24 hours before the first application of ozone, and 24 hours after each application. A sampling was carried out fifteen days after the last application, for a total of seven samplings and five applications of ozone per animal. From the obtained samples the hemograms and hematic biochemical components were determined, ALT, AST, ALP, total proteins, albumin, BUN, total bilirubin and direct bilirubin. Next, results and differences for each variable were presented. It was concluded that the application of ozone at therapeutic doses did not cause negative alterations in the hematology and blood biochemistry of equines.</p>References
Elvis AM, Ekta JS. Ozone therapy: A clinical review. J Nat Sci Bio Med. 2011;2(1): 66-70. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22470237/
Đuričić D, Valpotić H, Samardžija M. Prophylaxis and therapeutic potential of ozone in buiatrics: Current knowledge. Anim Reprod Sci. 2015;159: 1-7. Disponible en: https://doi.org/10.1016/j.anireprosci.2015.05.017
Sciorsci R, Lillo E, Occhiogrosso L, Rizzo A. Ozone therapy in veterinary medicine: A review. Res Vet Sci. 2020;130: 240-246. Disponible en: https://doi.org/10.1016/j.rvsc.2020.03.026
Do Prado Vendruscolo C, Junqueira Moreira J, Torquato Seidel S, Fülber J, Macedo Neuenschwander H, Bonagura G, et al. Effects of medical ozone upon healthy equine joints: Clinical and laboratorial aspects. Plos One. 2018; 13(5): 1-18. Disponible en: https://doi.org/10.1371/journal.pone.0197736
Schwartz Tapia A, Martínez-Sánchez G. La ozonoterapia y su fundamentación científica. Oz Therapy Glob J. 2012;12(1): 163-198. Disponible en: http://www.xn--revistaespaoladeozonoterapia-7xc.es/index.php/reo/article/view/23
Coelho C, Abreu-Bernadi W, Ginelli A, Spagnoll T, Gardel L, Sousa V. Use of ozone therapy in chronic laminitis in a horse. J Ozo Therapy. 2015;1(1): 2-7. Disponible en: https://doi.org/10.7203/jo3t.1.1.2015.12164
Garcia A, Eurides D, Prado R, Neves M, Neves S, Queiroz F. Skin healing in one equine by therapy with ozone. Rev C Cie Bio. 2010;41: 1-6. Disponible en: http://www.redalyc.org/articulo.oa?id=181220509033
Guerra Prado LG, Alves Martins NA, Ferreira Machado MF, Marques Araujo G. Ozonioterapia no tratamento de feridas em equino. R Cient Eletr Med Vet. 2020;(34): 6. Disponible en: https://www.bvs-vet.org.br/vetindex/periodicos/revista-cientifica-eletronica-de-medicinaveterina/2020-34/ozonioterapia-no-tratamento-de-feridas-em-equino/
Jaramillo FM, Vendruscolo CP, Fülber J, Seidel SRT, Barbosa AP, Baccarin RYA. Effects of transrectal medicinal ozone in horses-clinical and laboratory aspects. Arq Bras Med Vet Zoot. 2020;72(1): 56-64. Disponible en: https://doi.org/10.1590/1678-4162-11155
De Brito B, Rocha E, De Oliveira F, Dos Santos M. Aplicação da ozonioterapia na clínica de pequenos animais: vias de administração, indicações e efeitos adversos: Revisão. PUBVET. 2021;15(7):1-87. Disponible en: https://doi.org/10.31533/pubvet.v15n07a859.1-8
Cardona J, Reyes B, Martínez M. Cronometría dentaria en equinos. 1a Ed. Córdoba: Fondo Editorial Universidad de Córdoba; 2019.
Marques A, Campebell R. Ozonioterapia em feridas de equinos-revisão. Rev Cie Med Vet U. 2021;4(2): 31-45.
Guevara L. Efecto de la ozonoterapia sobre los parámetros hematológicos y constantes fisiológicas en equinos [Proyecto especial de Ingeniero Agrónomo]. Honduras: Zamorano; 2007. Disponible en: https://bdigital.zamorano.edu/bitstream/11036/716/1/T2416.pdf
Herrera Y, Rugeles C, Vergara O. Perfil hematológico del burro criollo (Equus asinus) colombiano. Rev Colombiana Cienc Anim. 2017;9(2): 158-163. Disponible en: https://doi.org/10.24188/recia.v9.n2.2017.553
Luna D, Hernández K, Chacha S, Cedeño Y. Determinación de los valores de referencia en el hemograma de caballos nacidos o criados entre 0 y 500 m.s.n.m. en la región litoral del Ecuador. La Granja: Rev Cie Vida. 2018;28(2): 92-102. Disponible en: http://scielo.senescyt.gob.ec/scielo.php?script=sci_abstract&pid=S1390-85962018000200092&lng=pt&nrm=iso
Díaz H, Gavidia C, Li O, Tió A. Valores hematológicos, bilirrubinemia y actividad enzimática sérica en caballos peruanos de paso del Valle de Lurín, Lima. Rev Inv Vet Perú. 2011;22(3): 213-222. Disponible en: http://www.redalyc.org/articulo.oa?id=371838856006
Haddad M, Souza M, Hincapie J, Ribeiro J, Ribeiro JD, Benjamin L. Comportamento de componentes bioquímicos do sangue em equinos submetidos à ozonioterapia. Arq Bras Med Vet Zootec. 2009;61(3): 539-546. Disponible en: https://doi.org/10.1590/S0102-09352009000300003
Ximenes L, Guerreiro L, Conceição W, Rosseto A, Borges G, Dos Santos Belo A, et al. Associated use of infrared thermography and ozone therapy for diagnosis and treatment of an inflammatory process in an equine: case report. PUBVET. 2020;14(3): 1-9. Disponible en: https://doi.org/10.31533/pubvet.v14n3a534.1-9
Assis A. Eficiência da Ozonioterapia como protocolo de tratamento alternativo das diversas enfermidades na Medicina Veterinária (Revisão de literatura). PUBVET. 2011;5(30): 1192-1198. Disponible en: http://dx.doi.org/10.22256/pubvet.v5n30.1194
Keywords
ozone
blood
intravenous