Molecular aspects of canine parvovirosis and its consequences in the desease

Abstract

Parvovirus canine type 2 is the causal agent of an infected - contagious disease that produces a hemorrhagic and acute gastroenteritis that affects young canines. The CPV-2 adapted to the canine species by mutation of the virus of the feline Panleucopenia (FPV) through their passage by wild animals like the ferret and the foxes. The great variability of the viral protein VP2 is the main cause of the wide host range, and crossed reactions among variants. The VP2 sequence has allowed identifying three variants of the virus like 2a, 2b and 2c which coexist in the world with differences in cellular tropism, pathogenesis and infection. The high genetic variation of a virus ssDNA in short periods of time indicates a high degree of selection by evolution just compared to RN virus. This high variation has not been completely clarified. The molecular techniques will allow differencing between vaccine strain and field strain as well as to have reliable and specific diagnosis techniques.