Remote injuries caused by ischemic- reperfusion syndrome in equines, physiopathology and therapeutic alternatives

Abstract

Injuries of the ischemia and reperfusion (I/R) syndrome in the different pathophysiological states from clinical situations, as well as in surgical procedures of high vascular and tissue manipulation, are of great importance in equine medicine; for that reason, most studies are made in the particularities of the equine specie due to the increase in frequency of presentation in intestinal accidents (White et al. 1980; Moore et al. 1995; Faleiros, 1997; Kooreman et al. 1998; Faleiros et al. 2002). In spite of the recent advances in therapeutics and surgical clinic, mortality in equines carrying strangling diseases is elevated, having great importance the intestinal ischemia. Similarly an efficient drug for the treatment of the injury by reperfusion in the clinical routine of the acute abdomen in equines is not available (Hinnebusch et al. 2002; Dabareiner et al. 1998). They either do not know absolutely the class of injuries that a problem in the vascularization could cause in organs highly employees in the vascular provision as heart, lungs, liver and kidney, because it is verified that the damage by reperfusion brings in consequence cellular death and endothelial dysfunction caused by the restoration of the blood flow (Alfonso et al. 2000).