Abstract
The lipopolysaccharide (LPS) or endotoxin is the major component of the outer membrane in Gram negative bacterial pathogens; it plays an important role in the activation of the immune system to be the most important surface antigen of Gram negative bacteria. The LPS consist of a lipophilic component and a polysaccharide portion with different function that makes this molecule one of the virulence factors more complex to understand, this review make an approach to measure the diversity effects and universality of LPS.