Vomit, Sialorrhea and Regurgitation as Clinical Signs of Focal Autonomic Seizures in Three Dogs

Abstract

<p>Focal seizures originate in a focal location of the brain with abnormal electric discharges due to different causes and may occur in a low percentage of animals and their signs are different from the typical tonic-clonic myoclony. This work aims to disclose some clinical cases of dogs with vomit, sialorrhea and regurgitation as clinical signs of focal seizures. In addition to these digestive signs, the dogs did not show any noteworthy alteration in the laboratory test results, neither in the complementary imaging methods included in the study. Due to the scant therapeutic response and as the dogs got worse (a serious loss of weight), having ruling out any peripheral cause of vomit and/or regurgitation, the possibility of a central cause was considered. The dogs underwent an electroencephalogram (EEG) and in all cases the EEG results showed anomalies. Due to the described clinical conditions, a phenobarbital treatment was administered and the three cases clinical cases evolved positively. Dogs with focal autonomic seizures may show various clinical symptoms depending on the damaged brain regions they come from. Therefore, it is important to consider a central cause —focal autonomic epilepsy— for the differential clinical signs such as the vomit, mostly when there is not a clearly diagnosed cause</p>
PDF (Spanish)

References

Berendt M, Farquhar RG, Mandigers PJ, Pakozdy A, Bhatti SF, De Risio L, et al. International veterinary epilepsy task force consensus report on epilepsy definition, classification and terminology in companion animals. BMC Veterinary Research. 2015;11(182):1-11. https://doi.org/10.1186/s12917-015-0461-2

Panayiotopoulos CP. The new ILAE report on terminology and concepts for organization of epileptic seizures: a clinician’s critical view and contribution. Epilepsia. 2011;52(12):2155-60. https://doi.org/10.1111/j.1528-1167.2011.03288.x

Fejerman N. Síndromes y enfermedades epilépticos. En Michell F, Nogués M, Asconapé J, Fernández MM, Biller J, editores. Tratado de neurología clínica. Buenos Aires: Editorial Médica Panamericana; 2002. p. 791-816.

Gagliano L, Bou Assi E, Nguyen DK, Rihana S, Sawan M. Bilateral preictal signature of phase-amplitude coupling in canine epilepsy. Epilepsy Res. 2018;139:123-8. https://doi.org/10.1016/j.eplepsyres.2017.11.009

Lorenz M, Coates J, Kent M. Seizures, narcolepsy, and cataplexy. En: Handbook of neurology veterinary. 5a. ed. St. Louis, MO: Elsevier/Saunders; 2012. p. 384-412. https://doi.org/10.1016/B978-1-4377-0651-2.10013-X

Sistema de Índice de Condición Corporal (BCS) para Perros y Gatos. En: Guías para la evaluación nutricional. Global Nutrition Committee Toolkit [internet]. World Small Animal Veterinary Association [citado 2020 feb. 15]. Disponible en: https://wsava.org/wp-content/uploads/2020/01/Global-Nutritional-Assesment-Guidelines-Spanish.pdf

Elwood C, Devauchelle P, Elliott J, Freiche V, German AJ, Gualtieri M, et al. Emesis in dogs: a review. J Small Anim Pract. 2010;51(1):4-22. https://doi.org/10.1111/j.1748-5827.2009.00820.x

Rosé A, Neiger R. Causes of vomiting in dogs and usefulness of clinical investigations. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2013;41(1):16-22. https://doi.org/10.1055/s-0038-1623680

Anwar H, Khan QU, Nadeem N, Pervaiz I, Ali M, Cheema FF. Epileptic seizures. Discoveries (Craiova, Romania). 2020;8(2):e110. https://doi.org/10.15190/d.2020.7

Kitz S, Thalhammer JG, Glantschnigg U, Wrzosek M, Klang A, Halasz P, et al. Feline Temporal lobe epilepsy: review of the experimental literature. J Vet Inter Med. 2017;31(3):633-40. https://doi.org/10.1111/jvim.14699

Leigh EJ, Mackillop E, Robertson ID, Hudson LC. Clinical anatomy of the canine brain using magnetic resonance imaging. Vet Radiol Ultrasound. 2008;49(2):113-21. https://doi.org/10.1111/j.1740-8261.2008.00336.x

Velez-Ruiz NJ, Klein JP. Neuroimaging in the evaluation of epilepsy. Semin Neurol. 2012;32(4):361-73. https://doi.org/10.1055/s-0032-1331809

Utsugi S, Saito M, Sato T, Kunimi M. Relationship between interictal epileptiform discharges under medetomidine sedation and clinical seizures in canine idiopathic epilepsy. Vet Rec. 2020;187(2):67. https://doi.org/10.1136/vr.104947

Czerwik A, Płonek M, Podgórski P, Wrzosek M. Comparison of electroencephalographic findings with hippocampal magnetic resonance imaging volumetry in dogs with idiopathic epilepsy. J Vet Intern Med. 2018;32(6):2037-44. https://doi.org/10.1111/jvim.15323

Martínez Barros M, Trout Guarriola G. Conceptos básicos de electroencefalografía. Revista de la Facultad de Ciencias de Salud. 2006;3(1):18-23.

Berendt M, Gredala H, Alvingb J. Characteristics and phenomenology of epileptic partial seizures in dogs: similarities with human seizure semiology. Epilepsy Res. 2004;(61):167-73. https://doi.org/10.1016/j.eplepsyres.2004.07.009

Keywords

focal seizures
electroencephalogram
autonomic signs