Acanthomatous ameloblastoma in canine (Canis lupus familiaris): case report

Abstract

The presence of neoplasms at the level of the oral cavity in dogs is evidenced by 9% in clinical studies, allowing a difference of 29% for benign cases and 32% for malignant cases. A 10-year-old female of the canine species, of the fox terrier breed, sterilized, living under the supervision of guardians. It was clinically evaluated by the presence of a proliferative mass with areas of hyperpigmentation at the level of the lower lip rostral to incisor and canine teeth at the level of the mandibular bone, with a compromise of the oral vestibule and sublingual caruncles. Histopathology indicated that the sample contains an abundant amount of dense, non-patterned fibroblastic tissue, with collagenous bundles in different directions, occasionally including well-differentiated bone tissue, which contains a medullary cavity. The morphopathological diagnosis consisted of an ossifying fibroma / acanthomatous ameloblastoma with ulcerative stomatitis. The case was approached from a surgical setting by means of a bilateral partial rostral mandibulectomy and the incorporation of an esophageal catheter, during the postoperative period. Through this report we seek to publicize presentations of this type of neoplasm and allow, through specific diagnoses, to make decisions that can support the quality of life of our patients.
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References

-Torres M, Peraza B, Fabré Y, Rodríguez J, Calaña L, Márquez M, . . Camacho C. Frecuencia de presentación de neoplasias en caninos del municipio San Miguel del Padrón, La Habana, Cuba. Rev Salud Anim. 2015;37(1):39-46.

-Verhaert L. Oral Proliferative Lesions in the Dog and Cat. Eur. j. companion anim. pract. 2010;20(3):1-13.

-Khanna C. The dog as a cancer model. Nat. Biotechnol. 2006;24(9):1065-1066. https://doi.org/10.1038/nbt0906-1065b

-Mikiewicz M, Pazdzior-Czapula K, Gesek M, Lemishevskyi V, Otrocka-Domagala I. Canine and Feline Oral Cavity Tumours and Tumour-like Lesions: a Retrospective Study of 486 Cases (2015-2017). J. Comp. Pathol. 2019;172:80-87. https://doi.org/10.1016/j.jcpa.2019.09.007

-Bell C, Soukup J. Nomenclature and Classification of Odontogenic Tumors - Part II: Clarification of Specific Nomenclature. J. Vet. Dent. 2014;31(4):234-243. https://doi.org/10.1177/089875641403100403

-Löhr CV. One hundred two tumors in 100 goats (1987-2011). Vet Pathol. 2013;50 (4):668–75. https://doi.org/10.1177/0300985812471544

-McEntee MC, Page RL, Théon A, Erb HN, Thrall DE. Malignant tumor formation in dogs previously irradiated for acanthomatous epulis. Vet. Radiol. Ultrasound. 2004;45(4):357-361. https://doi.org/10.1111/j.1740-8261.2004.04067.x

-Peralta S, Mcleary-Wheeler A, Duhamel G, Heikinheimo K, Grenier JK. Ultra-frequent HRAS p.Q61r somatic mutation in canine acanthomatous ameloblastoma reveals pathogenic similarities with human ameloblastoma. Vet Comp Oncol. 2019;17(3):439-445. https://doi.org/10.1111/vco.12487

-Schiffman JD, Breen M. Comparative oncology: what dogs and other species can teach us about humans with cancer. Phil. Trans. R. Soc. B. 2015;370:20140231 https://doi.org/10.1098/rstb.2014.0231

-Fiani N, Verstraete F, Kass P, Cox D. (2011). Clinicopathologic characterization of odontogenic tumors and focal fibrous hyperplasia in dogs: 152 cases (1995-2005). J Am Vet Med Assoc. 2011;238(4):495-500. https://doi.org/10.2460/javma.238.4.495

- Vail DM, Thamm DH, Liptak J. Withrow & Macewen’s Small Animal Clinical Oncology. St. Louis, Missouri: Saunders/Elsevier; 2012.

-Goldschmidt S, Bell C, Waller K., Hetzel S, Soukup J. Biological Behavior of Canine Acanthomatous Ameloblastoma Assessed With Computed Tomography and Histopathology: A Comparative Study. J. Vet. Dent. 2020;37(3):126-132. https://doi.org/10.1177/0898756420969869

-Hurtado R, Fernández V. (2020). Frecuencia y clasificación de neoplasias orales en pacientes caninos de la Clínica de Animales Menores de la Universidad Nacional Mayor de San Marcos (2009-2013). Rev. investig. vet. Perú. 2020;31(3):e18171. https://doi.org/10.15381/rivep.v31i3.18171

-Wingo K. Histopathologic Diagnoses From Biopsies of the Oral Cavity in 403 Dogs and 73 Cats. J. Vet. Dent. 2018;35(1):7-17. https://doi.org/10.1177/0898756418759760

- Malmberg JL, Howerth EW, Powers BE, Schaffer PA. Acanthomatous ameloblastoma with atypical foci in five dogs. J. Vet. Diagn. Invest. 2017;29(2):154-159 https://doi.org/10.1177/1040638716682565

- Quiroga AL, Gutiérrez-Silva M, Tapia-Ercoli M. Ameloblastoma acantomatoso en un perro: reporte de caso. Ces. Med. Vet. Zootec. 2016;11(1),110-115.

-S Stancu A, Stan F, Pentea M. Case report of canine achantomatous ameloblastoma. J. Food. Agric. Environ. 2012;10(3):664-666.

-Verstraete FJM. Mandibulectomy and Maxillectomy. Vet. Clin. Small. Anim. 2005;35(4):1009-1039. https://doi.org/10.1016/j.cvsm.2005.03.005

-Hasegawa T, Imai Y, Takeda D, Yasuoka D, Ri S, Shigeta T, Minamikawa T, Shibuya Y, Komori T. Retrospective study of ameloblastoma: The possibility of conservative treatment. Kobe J Med Sci. 2013;59(4):112-121.

-Yoshida K, Watarai Y, Sakai Y, Yanai T, Masegi T, Iwasaki T. The effect of intralesional bleomycin on canine acanthomatous epulis. J Am Anim Hosp Assoc. 1998;34(6):457-461. https://doi.org/10.5326/15473317-34-6-457

- Faustich JS, Stepaniuk KS, Robinson NA, Piedra-Mora C. Oral cavity. En: Veterinary Cytology. 1st ed. Hoboken: Wiley-Blackwell; 2021. p. 361-379. https://doi.org/10.1002/9781119380559.ch30

- Palić J, Heier A, Wohlsein P. Cytologic features of an acanthomatous ameloblastoma in a dog. Vet Clin Pathol. 2022;51(2):258-262. https://doi.org/10.1111/vcp.13080

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Keywords

neoplasia
ameloblastoma
mandibulectomy
histopathology
morphopathology