Abstract
African pygmy hedgehogs (Atelerix albiventris) are an increasingly more common pet worldwide. In such species, the highly invasive squamous cell carcinoma (SCC) clinical reports are even more usual. Our report presents a 7 years old indoor male African pygmy hedgehog, with a high grade and infiltrative SCC. Such condition induced left mandible caudal portion fracture, and tooth damage, clinically and radiologically evidenced. The patient presented progressive weight loose, and, finally, the euthanasia protocol was authorized by the owners. At necropsy, a 5-7 cm diameter whitish nodular, firm and solitary oral lesion was found, which caused oral damage and nasal turbinates compression. Also, another distant and solitary whitish nodular lesion was evidenced at the left lung cranial lobe. Histopathologic, histochemistry and immunohistochemical findings confirmed a high grade and infiltrative SCC with lung metastasis, and neoplastic emboli on lymph vessels both in oral and lung samples. Therefore, this is the first reported case with these histopathologic features.References
Heatley J, Mauldin G, Cho D. A review of neoplasia in the captive African hedgehog (Atelerix albiventris). Sem Avi Exot Pet Med. 2005;14(3): 182-192. Disponible en: https://doi.org/10.1053/j.saep.2005.07.002
Gardhouse S, Eshar D. Retrospective study of disease occurrence in captive African pygmy hedgehogs (Atelerix albiventris). Isr J Vet Med. 2015; 70(1): 32-36. Disponible en: https://www.ivis.org/library/israel-journal-of-veterinary-medicine/israel-journal-of-veterinary-medicine-vol-701-mar/retrospective-study-of-disease-occurrence-captive-african-pygmy-hedgehogs-atelerix-albiventris
Chaprazov T, Dimitrov R, Stamatova Yovcheva K, Uzunova K. Oral and dental disorders in pet hedgehogs. Turk J Vet Anim Sci. 2014;38(1): 1-6. Disponible en: https://doi.org/10.3906/vet-1302-46
Couture E, Langlois I, Santamaria-Bouvier A, Benoit-Biancamano M. Cutaneous squamous cell carcinoma in an African pygmy hedgehog (Atelerix albiventris). Can Vet J. 2015;56(12): 1275-1278. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668815/
Otrocka-Domagała I, Paździor-Czapula K, Fledorowicz J, Mikiewicz M, Piotrowska A, Gesek M. Cutaneous and subcutaneous tumors of small pet mammals-retrospective study of 256 cases (2014-2021). Anima. 2022;12(8): 1-16. Disponible en: https://doi.org/10.3390/ani12080965
Raymond J, Garner M. Mammary gland tumors in captive African hedgehogs. J Wildl Dis. 2000;36(2): 405-408. Disponible en: https://doi.org/10.7589/0090-3558-36.2.405
Kuonen V, Wilkie D, Morreale R, Oglesbee B, Barrett-Rephum K. Unilateral exophthalmia in a European hedgehogs (Erinaceus europaeus) caused by a lacrimal ductal carcinoma. Vet Ophthalmol. 2002;5(3): 161-165. Disponible en: https://doi.org/10.1046/j.1463-5224.2002.00236.x
Luff J, Rowland P, Mader M, Orr C, Yuan H. Two canine papillomaviruses associated with metastatic squamous cell carcinoma in two related Basenji dogs. Vety Pathol. 2016;53(6): 1160-1163. Disponible en: https://doi.org/10.1177/0300985816630795
Munday J, Aberdein D. Loss of retinoblastoma protein, but not p53, is associated with the presence of papillomaviral DNA in feline viral plaques, Bowenoid in situ carcinomas, and squamous cell carcinomas. Vet Pathol. 2012;49(3): 538-545. Disponible en: https://doi.org/10.1177/030098581141953
Munday JS. Bovine and human papillomaviruses: a comparative review. Vet Pathol. 2012;5(6): 1063-1075. Disponible en: https://doi.org/10.1177/0300985814537837
Ostrow R, McGleenen R, Shaver M, Kloster B, Houser S, Faras A. A rhesus monkey model for sexual transmission of papillomavirus isolated from squamous cell carcinoma. Proc Natl Acad Sci. 1990;87(20): 8170-8174. Disponible en: https://doi.org/10.1073/pnas.87.20.8170
Pei-Chi H, Jane-Fang Y, Lih-Chiann W. A retrospective study of the medical status on 63 African hedgehogs (Atelerix albiventris) at the Taipei Zoo from 2003 to 2011. J Exot Pet Med. 2015;24: 105-111. Disponible en: https://doi.org/10.1053/J.JEPM.2014.11.003
Spugnini E, Lanza A, Sebasti S, Baldi A. Electrochemotherapy palliation of an oral squamous cell carcinoma in an African hedgehog (Atelerix albiventris). Vet Res Forum. 2018;9(4): 379-381. Disponible en: https://doi.org/10.30466/vrf.2018.33109
Del Águila G, Torres C, Carvallo F, González C, Cifuentes F. Oral masses in African pygmy hedgehogs. J Vet Diagn Invest. 2019;31(6): 864-867. Disponible en: https://doi.org/10.1177/1040638719878870
Dhaliwal R, Kufuor-Mensah E. Metastatic squamous cell carcinoma in a cat. J Feline Med Surg. 2007;9(1): 61-66. Disponible en: https://doi.org/10.1016/j.jfms.2006.05.004
Soltero-Rivera M, Krick E, Reiter A, Brown D, Lewis J. Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005-2011). J Feline Med Surg. 2014;16(2): 164-169. Disponible en: https://doi.org/10.1177/1098612X13502975
Kandefer-Gola M, Ciaputa R, Sulima K, Miszczak M, Lachowska S, Nowak M. Metastatic mast cell tumour in African hedgehog: A case report. Vet Med- Czech. 2020;65(8): 371-376. Disponible en: https://doi.org/10.17221/17/2020-VETMED
Fernandes Silva G, Rêma A, Teixeira S, dos Anjos Pires M, Taulescu M, Amorim I. Pathological findings in African pygmy hedgehogs admitted into a Portuguese rehabilitation center. Animal. 2022;12(11): 1-17. Disponible en: https://doi.org/10.3390/ani12111361
Raymond J, White M. Necropsy and histopathologic findings in 14 African hedgehogs (Atelerix albiventris): a retrospective study. J Zoo Wildl Med. 1999;30(2): 273-277. Disponible en: https://pubmed.ncbi.nlm.nih.gov/10484145/
Keywords
squamous cell carcinoma
metastatic
neoplasm